x[idxs + 1] or x[idxs + 1L]? That is the question.
Assume that we have a vector $x$ of $n = 100,000$ random values, e.g.
> n <- 100000 > x <- rnorm(n) and that we wish to calculate the $n-1$ first-order differences $y=(y_1, y_2, …, y_{n-1})$ where $y_i=x_{i+1} - x_i$. In R, we can calculate this using the following vectorized form:
> idxs <- seq_len(n - 1) > y <- x[idxs + 1] - x[idxs] We can certainly do better if we turn to native code, but is there a more efficient way to implement this using plain R code?

Are you a good R citizen and preallocates your matrices? If you are allocating a numeric matrix in one of the following two ways, then you are doing it the wrong way!
x <- matrix(nrow = 500, ncol = 100) or
x <- matrix(NA, nrow = 500, ncol = 100) Why? Because it is counter productive. And why is that? In the above, x becomes a logical matrix, and not a numeric matrix as intended.